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Increase in the level of mRNA for 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice

Nakagawa Y, Asai H, Kitoh J, Mori H, Nakano K

Biosci Biotechnol Biochem. 1995 Nov;59(11):2191-2

We had shown that production of quinolinic acid is high in the brain of epilepsy-prone El mice and that this is due to an increase in the activity of 3-hydroxyanthranilate 3,4-dioxygenase (3-HAO, EC 1.13.11.6). We demonstrated here that the level of mRNA for 3-HAO was markedly increased in the brain of El mice.

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Gene(s): El1, El2, El3, El4, El5, El6