Cacng2

Species Mus musculus
Alternate Name(s) stg, wag, waggler, stargazer, stargazin
Description calcium channel, voltage-dependent, gamma subunit 2
Chromosome 15
Locus 15 45.2 cM
Human Homolog CACNG2
Reference(s) Chen L, Chetkovich DM, Petralia RS, Sweeney NT, Kawasaki Y, Wenthold RJ, Bredt DS, Nicoll RA. Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms. Nature. 2000 Dec 21-28;408(6815):936-43.

Chen L, El-Husseini A, Tomita S, Bredt DS, Nicoll RA. Stargazin differentially controls the trafficking of alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate and kainate receptors. Mol Pharmacol. 2003 Sep;64(3):703-6.

Chetkovich DM, Chen L, Stocker TJ, Nicoll RA, Bredt DS. Chetkovich DM, Chen L, Stocker TJ, Nicoll RA, Bredt DS. J Neurosci. 2002 Jul 15;22(14):5791-6.

Dakoji S, Tomita S, Karimzadegan S, Nicoll RA, Bredt DS. Interaction of transmembrane AMPA receptor regulatory proteins with multiple membrane associated guanylate kinases. Neuropharmacology. 2003 Nov;45(6):849-56.

Di Pasquale E, Keegan KD, Noebels JL. Increased excitability and inward rectification in layer V cortical pyramidal neurons in the epileptic mutant mouse Stargazer. J Neurophysiol. 1997 Feb;77(2):621-31.

El-Husseini Ael-D, Schnell E, Dakoji S, Sweeney N, Zhou Q, Prange O, Gauthier-Campbell C, Aguilera-Moreno A, Nicoll RA, Bredt DS. Synaptic strength regulated by palmitate cycling on PSD-95. Cell. 2002 Mar 22;108(6):849-63.

Kang MG, Chen CC, Felix R, Letts VA, Frankel WN, Mori Y, Campbell KP. Biochemical and biophysical evidence for gamma 2 subunit association with neuronal voltage-activated Ca2+ channels. J Biol Chem. 2001 Aug 31;276(35):32917-24. Epub 2001 Jul 05.

Khan Z, Carey J, Park HJ, Lehar M, Lasker D, Jinnah HA. Abnormal motor behavior and vestibular dysfunction in the stargazer mouse mutant. Neuroscience. 2004;127(3):785-96.

Letts VA, Felix R, Biddlecome GH, Arikkath J, Mahaffey CL, Valenzuela A, Bartlett FS 2nd, Mori Y, Campbell KP, Frankel WN. The mouse stargazer gene encodes a neuronal Ca2+-channel gamma subunit. Nat Genet. 1998 Aug;19(4):340-7.

Letts VA, Kang MG, Mahaffey CL, Beyer B, Tenbrink H, Campbell KP, Frankel WN. Phenotypic heterogeneity in the stargazin allelic series. Mamm Genome. 2003 Aug;14(8):506-13.

Noebels JL, Qiao X, Bronson RT, Spencer C, Davisson MT. Stargazer: a new neurological mutant on chromosome 15 in the mouse with prolonged cortical seizures. Epilepsy Res. 1990 Nov;7(2):129-35.

Price MG, Davis CF, Deng F, Burgess DL. The alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate receptor trafficking regulator "stargazin" is related to the claudin family of proteins by Its ability to mediate cell-cell adhesion. J Biol Chem. 2005 May 20;280(20):19711-20. Epub 2005 Mar 10.

Price MG, Davis CF, Deng F, Burgess DL. The AMPA receptor trafficking regulator stargazin is related to the Claudin family of proteins by its ability to mediate cell-cell adhesion. J Biol Chem. 2005 Mar 10; [Epub ahead of print].

Qiao X, Noebels JL. Developmental analysis of hippocampal mossy fiber outgrowth in a mutant mouse with inherited spike-wave seizures. J Neurosci. 1993 Nov;13(11):4622-35.

Qiao XX, Noebels JL. Genetic and phenotypic heterogeneity of inherited spike-wave epilepsy: two mutant gene loci with independent cerebral excitability defects. Brain Res. 1991 Jul 26;555(1):43-50.

Schnell E, Sizemore M, Karimzadegan S, Chen L, Bredt DS, Nicoll RA. Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13902-7. Epub 2002 Oct 1.

Tomita S, Chen L, Kawasaki Y, Petralia RS, Wenthold RJ, Nicoll RA, Bredt DS. Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins. J Cell Biol. 2003 May 26;161(4):805-16.

Tomita S, Fukata M, Nicoll RA, Bredt DS. Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses. Science. 2004 Mar 5;303(5663):1508-11.

Tomita S, Stein V, Stocker TJ, Nicoll RA, Bredt DS. Bidirectional synaptic plasticity regulated by phosphorylation of stargazin-like TARPs. Neuron. 2005 Jan 20;45(2):269-77.

Vandenberghe W, Nicoll RA, Bredt DS. Interaction with the unfolded protein response reveals a role for stargazin in biosynthetic AMPA receptor transport. J Neurosci. 2005 Feb 2;25(5):1095-102.

Vandenberghe W, Nicoll RA, Bredt DS. Stargazin is an AMPA receptor auxiliary subunit. Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):485-90. Epub 2005 Jan 3.

Zhang Y, Mori M, Burgess DL, Noebels JL. Mutations in high-voltage-activated calcium channel genes stimulate low-voltage-activated currents in mouse thalamic relay neurons. J Neurosci. 2002 Aug 1;22(15):6362-71.

[Entrez Cross-Database Search] [Entrez Gene] [Pfam] [Swiss-Prot] [UniProt] [Allen Brain Atlas]