Prnp

Species Mus musculus
Alternate Name(s) PrP, PrPC, Sinc, CD230, PrPSc, Prn-i, Prn-p
Description prion protein
Chromosome 2
Locus 2 75.0 cM
Human Homolog PRNP
Protein Alignment Homo sapiens:

Mus musculus:
Reference(s) Kuramoto, T, Mori, M, Yamada, J and Serikawa, T. Tremor and zitter, causative mutant genes for epilepsy with spongiform encephalopathy in spontaneously epileptic rat (ser), are tightly linked to synaptobrevin-2 and prion proteins, respectively. Biochemical and Biophysical Research Communication, 200:1161-1168, 1994.

Rangel A, Burgaya F, Gavin R, Soriano E, Aguzzi A, Del Rio JA. Enhanced susceptibility of Prnp-deficient mice to kainate-induced seizures, neuronal apoptosis, and death: Role of AMPA/kainate receptors. Journal of Neuroscience Research. 2007 Feb 15; [Epub ahead of print].

Walz R, Amaral OB, Rockenbach IC, Roesler R, Izquierdo I, Cavalheiro EA, Martins VR, Brentani RR. Increased sensitivity to seizures in mice lacking cellular prion protein. Epilepsia. 1999 Dec;40(12):1679-82.

Walz R, Castro RM, Velasco TR, Carlotti CG Jr, Sakamoto AC, Brentani RR, Martins VR. Cellular prion protein: implications in seizures and epilepsy. Cell Mol Neurobiol. 2002 Jun;22(3):249-57.

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