Gabrb3

Species Mus musculus
Alternate Name(s) Cp1, Gabrb-3, A230092K12Rik
Description gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3
Chromosome 7
Locus 7 28.6 cM
Human Homolog GABRB3
Protein Alignment Homo sapiens:

Mus musculus:
Reference(s) DeLorey TM, Handforth A, Anagnostaras SG, Homanics GE, Minassian BA, Asatourian A, Fanselow MS, Delgado-Escueta A, Ellison GD, Olsen RW. Mice lacking the beta3 subunit of the GABAA receptor have the epilepsy phenotype and many of the behavioral characteristics of Angelman syndrome. J Neurosci. 1998 Oct 15;18(20):8505-14.

DeLorey TM, Olsen RW. GABA and epileptogenesis: comparing gabrb3 gene-deficient mice with Angelman syndrome in man. Epilepsy Res. 1999 Sep;36(2-3):123-32.

Liljelund P, Ferguson C, Homanics G, Olsen RW. Long-term effects of diazepam treatment of epileptic GABA(A) receptor beta3 subunit knockout mouse in early life. Epilepsy Res. 2005 Sep 13; [Epub ahead of print].

Terunuma M, Xu J, Vithlani M, Sieghart W, Kittler J, Pangalos M, Haydon PG, Coulter DA, Moss SJ. Deficits in phosphorylation of GABA(A) receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus. J Neurosci. 2008 Jan 9;28(2):376-84.

[Entrez Cross-Database Search] [Entrez Gene] [Pfam] [Swiss-Prot] [UniProt] [Allen Brain Atlas]