| Species |
Homo sapiens |
| Alternate Name(s) |
NR1, NMDA1, NMDAR1 |
| Epilepsy-Associated Disorder(s) |
temporal lobe epilepsy |
| Description |
glutamate receptor, ionotropic, N-methyl D-aspartate 1
|
| Chromosome |
9
|
| Locus |
9q34.3 |
| Mouse Homolog |
Grin1
|
| Rat Homolog |
Grin1
|
| Protein Alignment |
Homo sapiens:
Mus musculus:
Rattus norvegicus:
 |
| Reference(s) |
Aronica E, Leenstra S, Jansen GH, van Veelen CW, Yankaya B, Troost D. Expression of brain-derived neurotrophic factor and tyrosine kinase B receptor proteins in glioneuronal tumors from patients with intractable epilepsy: colocalization with N-methyl-D-aspartic acid receptor. Acta Neuropathol (Berl). 2001 Apr;101(4):383-92.
Blumcke I, Beck H, Scheffler B, Hof PR, Morrison JH, Wolf HK, Schramm J, Elger CE, Wiestler OD. Altered distribution of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit GluR2(4) and the N-methyl-D-aspartate receptor subunit NMDAR1 in the hippocampus of patients with temporal lobe epilepsy. Acta Neuropathol (Berl). 1996 Dec;92(6):576-87.
During MJ, Symes CW, Lawlor PA, Lin J, Dunning J, Fitzsimons HL, Poulsen D, Leone P, Xu R, Dicker BL, Lipski J, Young D. An oral vaccine against NMDAR1 with efficacy in experimental stroke and epilepsy. Science. 2000 Feb 25;287(5457):1453-60.
Mikuni N, Babb TL, Ying Z, Najm I, Nishiyama K, Wylie C, Yacubova K, Okamoto T, Bingaman W. NMDA-receptors 1 and 2A/B coassembly increased in human epileptic focal cortical dysplasia. Epilepsia. 1999 Dec;40(12):1683-7.
Musshoff U, Schunke U, Kohling R, Speckmann EJ. Alternative splicing of the NMDAR1 glutamate receptor subunit in human temporal lobe epilepsy. Brain Res Mol Brain Res. 2000 Mar 29;76(2):377-84.
Neder L, Valente V, Carlotti CG Jr, Leite JP, Assirati JA, Paco-Larson ML, Moreira JE. Glutamate NMDA receptor subunit R1 and GAD mRNA expression in human temporal lobe epilepsy. Cell Mol Neurobiol. 2002 Dec;22(5-6):689-98.
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