Cacnb4

Species Mus musculus
Alternate Name(s) lh, Cchb4, MGC31529, lethargic
Description calcium channel, voltage-dependent, beta 4 subunit
Chromosome 2
Locus 2 31.5 cM
Human Homolog CACNB4
Protein Alignment Homo sapiens:

Mus musculus:
Reference(s) Caddick SJ, Wang C, Fletcher CF, Jenkins NA, Copeland NG, Hosford DA. Excitatory but not inhibitory synaptic transmission is reduced in lethargic (Cacnb4(lh)) and tottering (Cacna1atg) mouse thalami. J Neurophysiol. 1999 May;81(5):2066-74.

Escayg A, Jones JM, Kearney JA, Hitchcock PF, Meisler MH. Calcium channel beta 4 (CACNB4): human ortholog of the mouse epilepsy gene lethargic. Genomics. 1998 May 15;50(1):14-22.

Khan Z, Jinnah HA. Paroxysmal dyskinesias in the lethargic mouse mutant. J Neurosci. 2002 Sep 15;22(18):8193-200.

Lin F, Barun S, Lutz CM, Wang Y, Hosford DA. Decreased (45)Ca(2)(+) uptake in P/Q-type calcium channels in homozygous lethargic (Cacnb4lh) mice is associated with increased beta3 and decreased beta4 calcium channel subunit mRNA expression. Brain Res Mol Brain Res. 1999 Jul 23;71(1):1-10.

Lin F, Wang Y, Hosford DA. Age-related relationship between mRNA expression of GABA(B) receptors and calcium channel beta4 subunits in cacnb4lh mice. Brain Res Mol Brain Res. 1999 Jul 23;71(1):131-5.

McEnery MW, Copeland TD, Vance CL. Altered expression and assembly of N-type calcium channel alpha1B and beta subunits in epileptic lethargic (lh/lh) mouse. J Biol Chem. 1998 Aug 21;273(34):21435-8.

Zhang Y, Mori M, Burgess DL, Noebels JL. Mutations in high-voltage-activated calcium channel genes stimulate low-voltage-activated currents in mouse thalamic relay neurons. J Neurosci. 2002 Aug 1;22(15):6362-71.

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