Author
Chromosome
Description
Gene
Keyword
Species
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Cacnb4
Species
Mus musculus
Alternate Name(s)
lh, Cchb4, MGC31529, lethargic
Description
calcium channel, voltage-dependent, beta 4 subunit
Chromosome
2
Locus
2 31.5 cM
Human Homolog
CACNB4
Protein Alignment
Homo sapiens:
Mus musculus:
Reference(s)
Caddick SJ, Wang C, Fletcher CF, Jenkins NA, Copeland NG, Hosford DA.
Excitatory but not inhibitory synaptic transmission is reduced in lethargic (Cacnb4(lh)) and tottering (Cacna1atg) mouse thalami
. J Neurophysiol. 1999 May;81(5):2066-74.
Escayg A, Jones JM, Kearney JA, Hitchcock PF, Meisler MH.
Calcium channel beta 4 (CACNB4): human ortholog of the mouse epilepsy gene lethargic
. Genomics. 1998 May 15;50(1):14-22.
Khan Z, Jinnah HA.
Paroxysmal dyskinesias in the lethargic mouse mutant
. J Neurosci. 2002 Sep 15;22(18):8193-200.
Lin F, Barun S, Lutz CM, Wang Y, Hosford DA.
Decreased (45)Ca(2)(+) uptake in P/Q-type calcium channels in homozygous lethargic (Cacnb4lh) mice is associated with increased beta3 and decreased beta4 calcium channel subunit mRNA expression
. Brain Res Mol Brain Res. 1999 Jul 23;71(1):1-10.
Lin F, Wang Y, Hosford DA.
Age-related relationship between mRNA expression of GABA(B) receptors and calcium channel beta4 subunits in cacnb4lh mice
. Brain Res Mol Brain Res. 1999 Jul 23;71(1):131-5.
McEnery MW, Copeland TD, Vance CL.
Altered expression and assembly of N-type calcium channel alpha1B and beta subunits in epileptic lethargic (lh/lh) mouse
. J Biol Chem. 1998 Aug 21;273(34):21435-8.
Zhang Y, Mori M, Burgess DL, Noebels JL.
Mutations in high-voltage-activated calcium channel genes stimulate low-voltage-activated currents in mouse thalamic relay neurons
. J Neurosci. 2002 Aug 1;22(15):6362-71.
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