| Species |
Homo sapiens |
| Alternate Name(s) |
MGC34632 |
| Epilepsy-Associated Disorder(s) |
chronic partial epilepsy |
| Description |
brain-derived neurotrophic factor
|
| Chromosome |
11
|
| Locus |
11p13 |
| Mouse Homolog |
Bdnf
|
| Rat Homolog |
Bdnf
|
| Protein Alignment |
Homo sapiens:
Mus musculus:
Rattus norvegicus:
 |
| Reference(s) |
Aronica E, Leenstra S, Jansen GH, van Veelen CW, Yankaya B, Troost D. Expression of brain-derived neurotrophic factor and tyrosine kinase B receptor proteins in glioneuronal tumors from patients with intractable epilepsy: colocalization with N-methyl-D-aspartic acid receptor. Acta Neuropathol (Berl). 2001 Apr;101(4):383-92.
Bovolenta R, Zucchini S, Paradiso B, Rodi D, Merigo F, Navarro Mora G, Osculati F, Berto E, Marconi P, Marzola A, Fabene PF, Simonato M. Hippocampal FGF-2 and BDNF overexpression attenuates epileptogenesis-associated neuroinflammation and reduces spontaneous recurrent seizures. J Neuroinflammation. 2010 Nov 18;7:81.
Chou I, Chang-Hai T, Cheng-Chun L, Sheng-Shing L, Fuu-Jen T. Brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms in febrile seizures. Epilepsy Res. 2004 June;60(1):27-29
Kanemoto K, Kawasaki J, Tarao Y, Kumaki T, Oshima T, Kaji R, Nishimura M. Association of partial epilepsy with brain-derived neurotrophic factor (BDNF) gene polymorphisms. Epilepsy Res. 2003 Mar;53(3):255-8.
Koyama R, Yamada MK, Fujisawa S, Katoh-Semba R, Matsuki N, Ikegaya Y. Brain-derived neurotrophic factor induces hyperexcitable reentrant circuits in the dentate gyrus. J Neurosci. 2004 Aug 18;24(33):9215-24.
Lohoff FW, Ferraro TN, Dahl JP, Hildebrandt MA, Scattergood TM, O'connor MJ, Sperling MR, Dlugos DJ, Berrettini WH, Buono RJ. Lack of association between variations in the brain-derived neurotrophic factor (BDNF) gene and temporal lobe epilepsy. Epilepsy Res. 2005 Aug 13; [Epub ahead of print].
Palma E, Torchia G, Limatola C, Trettel F, Arcella A, Cantore G, Di Gennaro G, Manfredi M, Esposito V, Quarato PP, Miledi R, Eusebi F. BDNF modulates GABAA receptors microtransplanted from the human epileptic brain to Xenopus oocytes. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1667-72. Epub 2005 Jan 21.
Revuelta M, Castano A, Machado A, Cano J, Venero JL. Kainate-induced zinc translocation from presynaptic terminals causes neuronal and astroglial cell death and mRNA loss of BDNF receptors in the hippocampal formation and amygdala. J Neurosci Res. 2005 Sep 20; [Epub ahead of print].
Scharfman HE, Goodman JH, Sollas AL, Croll SD. Spontaneous limbic seizures after intrahippocampal infusion of brain-derived neurotrophic factor. Exp Neurol. 2002 Apr;174(2):201-14.
Tongiorgi E, Armellin M, Giulianini PG, Bregola G, Zucchini S, Paradiso B, Steward O, Cattaneo A, Simonato M. Brain-derived neurotrophic factor mRNA and protein are targeted to discrete dendritic laminas by events that trigger epileptogenesis. J Neurosci. 2004 Jul 28;24(30):6842-52.
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