Lis1

Species Mus musculus
Alternate Name(s) Pafah1b1, Mdsh, LIS-1, Ms10u, Pafaha, MMS10-U
Description platelet-activating factor acetylhydrolase, isoform 1b, beta1 subunit
Chromosome 11
Locus 11 44.0 cM
Human Homolog LIS1
Worm Homolog lis-1
Protein Alignment Homo sapiens:

Mus musculus:
Reference(s) Assadi AH, Zhang G, Beffert U, McNeil RS, Renfro AL, Niu S, Quattrocchi CC, Antalffy BA, Sheldon M, Armstrong DD, Wynshaw-Boris A, Herz J, D'Arcangelo G, Clark GD. Interaction of reelin signaling and Lis1 in brain development. Nat Genet. 2003 Nov;35(3):270-6. Epub 2003 Oct 26.

Fleck MW, Hirotsune S, Gambello MJ, Phillips-Tansey E, Suares G, Mervis RF, Wynshaw-Boris A, McBain CJ. Hippocampal abnormalities and enhanced excitability in a murine model of human lissencephaly. J Neurosci. 2000 Apr 1;20(7):2439-50.

Greenwood JS, Wang Y, Estrada RC, Ackerman L, Ohara PT, Baraban SC. Seizures, enhanced excitation, and increased vesicle number in Lis1 mutant mice. Ann Neurol. 2009 Nov;66(5):644-53.

Kholmanskikh SS, Dobrin JS, Wynshaw-Boris A, Letourneau PC, Ross ME. Disregulated RhoGTPases and actin cytoskeleton contribute to the migration defect in Lis1-deficient neurons. J Neurosci. 2003 Sep 24;23(25):8673-81.

McManus MF, Nasrallah IM, Pancoast MM, Wynshaw-Boris A, Golden JA. Lis1 is necessary for normal non-radial migration of inhibitory interneurons. Am J Pathol. 2004 Sep;165(3):775-84.

Pancoast M, Dobyns W, Golden JA. Interneuron deficits in patients with the Miller-Dieker syndrome. Acta Neuropathol (Berl). 2005 Mar 1; [Epub ahead of print].

Williams SN, Locke CJ, Braden AL, Caldwell KA, Caldwell GA. Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in C. elegans. Hum Mol Genet. 2004 Sep 15;13(18):2043-59. Epub 2004 Jul 14.

Zhang G, Assadi AH, McNeil RS, Beffert U, Wynshaw-Boris A, Herz J, Clark GD, D'Arcangelo G. The Pafah1b Complex Interacts with the Reelin Receptor VLDLR. PLoS ONE. 2007 Feb 28;2:e252.

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